Scribe Therapeutics→
Scientist I/II, mRNA Drug Substance Process… at Scribe… · Alameda
Job Description
- Base Pay: 120,000.00 - 160,000.00 / Year
- Employee Type: Exempt - FT
- Required Degree: Doctorate
Description
About Scribe:
Scribe Therapeutics is a clinical-stage biotechnology company engineering CRISPR-based technologies into purpose-built in vivo genetic medicines designed to become standard of care treatments for patients suffering from highly prevalent diseases, starting with cardiometabolic disease. Leveraging its CRISPR by Design™ approach and nature’s blueprint for improved cardiovascular health, Scribe’s initial programs focus on addressing the key drivers of ASCVD such as elevated LDL-C, lipoprotein(a), and triglycerides. The company’s lead candidate, STX-1150, is a novel liver-targeted therapy designed to epigenetically silence the PCSK9 gene and reduce LDL-C levels without inducing permanent DNA changes. To broaden and accelerate the impact of its engineered CRISPR technologies for patients, Scribe has formed strategic collaborations with world-leading pharmaceutical companies including Sanofi and Eli Lilly. Co-founded by Nobel Prize winner Jennifer Doudna and backed by leading life sciences investors, Scribe is advancing scalable, transformative, and preventative genetic medicines with the goal of improving outcomes and democratizing access to the protective effects of beneficial human genetics.
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Position Summary:
We are looking for a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. We are seeking a motivated and technically skilled Scientist I/II to support hands-on mRNA drug substance process development for Scribe's therapeutic programs. This role offers the opportunity to develop and optimize mRNA manufacturing processes to support the advancement of new mRNA candidates from early development through clinical manufacturing. The successful candidate will design and execute laboratory-scale studies across in vitro transcription (IVT), chromatography, and tangential flow filtration (TFF), generating data to guide process development and manufacturing decisions.
The ideal candidate has a strong background in biopharmaceutical process development, with experience in experimental design, process optimization, and troubleshooting. They should enjoy hands-on laboratory work, demonstrate scientific curiosity and initiative, and translate experimental results into clear technical recommendations. Experience with mRNA manufacturing processes, particularly IVT and purification, is highly desirable.
For Scientist II consideration, candidates should demonstrate the ability to independently identify process development needs, design experimental strategies, troubleshoot technical challenges, and drive defined development activities with minimal supervision.
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Competencies:
- mRNA Drug Substance Process Development
- IVT & mRNA Purification
- Tangential Flow Filtration
- Chromatography
- Manufacturability Assessment
- Experimental Design & Data Analysis
- Technical Documentation
- Cross-Functional Collaboration
- Scientific Rigor
- Lab Safety
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Key Duties / Responsibilities / “What you’ll do”:
- Design and execute laboratory-scale mRNA drug substance process development studies across IVT, chromatography, TFF, and related unit operations.
- Develop and execute manufacturability assessments for new mRNA candidates, evaluating IVT productivity, purification performance, mRNA integrity, impurity clearance, and overall process performance.
- Develop, optimize, and troubleshoot IVT processes, including evaluation of reaction conditions, productivity, and mRNA integrity.
- Develop, optimize, and troubleshoot TFF processes, including evaluation of membranes, operating parameters, concentration and diafiltration conditions, and product recovery.
- Support optimization and troubleshooting of chromatography and other mRNA purification operations.
- Identify process development needs, design experimental approaches, analyze results, and recommend subsequent development activities.
- Execute established in-process analytical methods, including mRNA concentration by UV absorbance and integrity by Fragment Analyzer, to support process development studies.
- Support CDMO process development, technology transfer, and engineering and GMP manufacturing activities, including review of process data and technical documentation and on-site support as needed.
- Prepare study plans, experimental records, protocols, technical reports, and development summaries, maintaining accurate documentation and contributing to internal mRNA DS process knowledge.
- Collaborate with Analytical Development, Drug Product, Quality, and other cross-functional teams to support mRNA development and manufacturing.
Requirements
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Knowledge Requirements (Background/Skills/Experience):
- PhD in chemical engineering, biochemical engineering, bioengineering, biochemistry, molecular biology, pharmaceutical sciences, or a related field, or an equivalent combination of education and relevant industry experience.
- Hands-on experience in biopharmaceutical process development, preferably involving mRNA, RNA, nucleic acids, or other complex biologics.
- Experience with process development unit operations, such as IVT, TFF, chromatography, or other nucleic acid processing techniques.
- Demonstrated ability to design and execute laboratory experiments, analyze data, troubleshoot technical challenges, and recommend subsequent development activities, with a level of independence appropriate to experience.
- Strong laboratory and organizational skills, with a commitment to data quality, reproducibility, accurate documentation, and laboratory safety.
- Excellent written and verbal communication skills, with the ability to collaborate effectively across functions in a fast-paced development environment.
Preferred Requirements:
- Hands-on experience with mRNA IVT and purification processes.
- Experience developing, optimizing, or scaling TFF processes.
- Experience with Oligo(dT) affinity chromatography or other nucleic acid purification technologies.
- Familiarity with mRNA analytical methods, including UV absorbance and Fragment Analyzer.
- Experience with process scale-up, technology transfer, CDMO-supported development, or engineering and GMP manufacturing activities.
- Familiarity with CMC development, GMP documentation, and electronic laboratory notebook systems such as Benchling.
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Physical Requirements:
- Ability to work in a laboratory environment and operate process development and analytical equipment safely.
- Ability to stand or sit for extended periods and perform laboratory tasks requiring manual dexterity.
- Ability to lift and move laboratory supplies weighing up to 15 pounds, with or without reasonable accommodation.
Summary
Benefits & Compensation:
Salary and total compensation will be commensurate with experience and will include a competitive benefits package. Scribe provides an intellectually stimulating, collegial, and fast-paced environment. If you are ready to help engineer the future of therapeutics, we are excited to hear from you. Visit us at www.scribetx.com.
- Health: Medical (HMO, PPO, EPO, HDHP), Dental, Vision, Life, Transit, FSA, HSA
- Equity: Meaningful equity that allows you to share in the long-term success of the platform.
- Perks: Wellness stipend, Learning and development opportunities, Cell stipend, home office set up stipend.
Equal Opportunity Employer
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, or any other characteristic protected by applicable law.