Director, Heme CGT Operations at Vertex Pharmaceuticals in Boston, MA

Director, Heme CGT Operations Location: Boston, MA Job Description About Vertex: At Vertex, we are relentless in our pursuit of transformative medicines to improve the lives of people with serious diseases. Building on a strong foundation of advancing therapies for cystic fibrosis, Vertex continues to expand its leadership across multiple disease areas, including cell and gene therapies, with the goal of delivering meaningful impact for patients worldwide. Our Global Heme Cell and Gene Therapy (CGT) Operations team is at the forefront of innovation, commercial strategy, and operational excellence, driving the evolution of the global, cross-functional, "vein to vein” business process for CASGEVY, the only CRISPR-based autologous gene therapy approved for people living with Sickle Cell Disease and Transfusion dependent beta thalassemia. Position Summary: We are seeking a Director, Heme CGT Operations to lead global operational strategy for CASGEVY.  This critical role will lead a team responsible for owning the global end-to-end business process, order management system, and treatment center strategy and communications, essential to delivering a vein-to-vein, autologous product.  As CASGEVY continues to scale across 9+ markets globally, the successful candidate will bring a strategic, operational, and collaborative mindset, provide cross-functional leadership and drive alignment among international and US Heme Business Units, Manufacturing, Quality, and Technology teams involved in CASGEVY delivery. Key Responsibilities: Lead Global operational strategy and spearhead forward-looking workstreams to advance business priorities emerging from the Disease Strategy Team and commercial business units to drive key program KPIs, developing and executing operational plans in close partnership with regional commercial teams and with senior leadership input and awareness Shape evolution of end-to-end business process and chain-of-identify / chain-of-custody order management portal (“Vertex Connects”) critical to vein-to-vein delivery of CASGEVY across markets, overseeing execution of optimizations and ensuring business readiness and GxP compliance for launch of process and system changes Collaborate closely with regional commercial teams to address in-market needs and operational challenges based on customer feedback and analytics, designing and operationalizing solutions in partnership with quality, manufacturing, and technology teams Manage evolution of global treatment center strategy, requirements, and communications to ensure seamless and consistent CASGEVY treatment journey globally and drive external transparency around process and operations Lead Global Cell and Gene Therapy Ops cross-functional team, a sub-team of the Disease Strategy Team, driving internal alignment on business process and priorities and serving as subject matter expert, liaison, and facilitator to ensure integration of commercial strategy into business operations and vice versa Manage Global CGT Ops team, setting strategy and priorities, managing and coaching team and ensuring responsible management of external spend & vendors Qualifications and Experience: 10+ years of relevant experience in biotechnology, pharmaceuticals, or advanced therapy operations. Strong analytical and problem-solving skills with the ability to translate strategy into execution. Demonstrated success working in cross-functional, matrixed organizations with multiple stakeholders. Strong leadership, communication, and influencing skills with the ability to operate effectively at both strategic and execution levels. Proven ability to manage competing priorities and drive results in a fast-paced environment. Experience supporting commercialization or launch planning for advanced therapies, such as autologous gene therapies Experience influencing senior leaders and presenting within executive governance forums. Continuous improvement mindset with the ability to optimize processes across complex organizations. Pay Range: $196,000 - $294,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1.    Hybrid: work remotely up to two days per week; or select 2.    On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com