Co-op: Quality Control at Prime Medicine, Inc. in Cambridge, MA

Summary: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The co-op position in Quality Control will involve supporting analytical testing for gene therapy programs and gaining hands-on experience with cutting-edge analytical technologies. Responsibilities: - Support product development sample analyses, in-process, release, and stability testing for LNP-based drug products, prime editing component RNAs, and cell-based drug products - Execute and support cell-based analytical activities - Perform cell-based potency, viability, conduct cell counting - Assist with optimization, troubleshooting, validation, and qualification of analytical methods - Participate in stability and reference standard programs including protocol/report preparation, data compilation, trending, and analysis - Assist with sample management and chain-of-custody documentation - Conduct clean room laboratory environmental monitoring for GMP manufacturing suites - Document and communicate experimental data in electronic notebooks and quality systems in accordance with cGMP requirements - Collaborate cross-functionally with Analytical Development, Manufacturing, MSAT, and Program Teams to support product and method development and qualification/validation - Contribute to laboratory functionality, safety compliance, and QC process optimization - Identify opportunities for assay optimization, workflow improvements, and automation - Demonstrate flexibility in supporting new projects, troubleshooting activities, and evolving program priorities Required Qualifications: - Currently enrolled in a B.S. or M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, Pharmacology, or related field - Completion of foundational biology, biochemistry, microbiology, chemistry, and/or cell biology coursework with laboratory components - Experience with aseptic technique and basic cell culture is highly desirable, or liquid nanoparticle technology - Ability to work both independently and collaboratively - Self-motivated, detail-oriented, and organized with strong problem-solving skills - Excellent verbal and written communication skills - Eagerness to learn GLP/GMP practices and analytical methodologies - Comfortable engaging in cross-functional teamwork - Ability to manage multiple projects in a dynamic, fast-paced environment Preferred Qualifications: - Understanding of fundamental principles behind biological and chemical analytical techniques such as UV-Vis, HPLC/UPLC, LC-MS, PCR/qPCR/ddPCR, and potency assays - Hands-on experience with biological or chemical analytical techniques including sample preparation, dilution, extraction, and analysis - Experience with cell-based assays (e.g., viability assays, flow cytometry, functional assays) - Familiarity with cell therapy or gene editing technologies - Prior internship or co-op experience in the biotechnology industry Required Skills: Biological techniques, Chemical techniques, Cell culture Important Skills: Analytical methodologies, Aseptic technique, Cell-based assays Nice-to-Have Skills: Self-motivated Benefits: Comprehensive Total Rewards package, Robust health, financial, and wellness benefits, Medical, Dental, Vision, Life insurance, 401(k) match, Equity programs, Generous paid time off, Wellness days, Company-wide recharge breaks