Senior People Business Partner, Commercial at Praxis… · Location…

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity Praxis is evolving from a clinical-stage company into a commercial organization, one that is built to deliver for patients at scale.  You will help make that transition real through partnership with Praxis’s Commercial organization as we build a high-performing, patient-centered team capable of delivering impact at speed. In this role, you will operate as both a strategic advisor and a hands-on builder, shaping organizational design, coaching leaders, and driving talent decisions while also rolling up your sleeves to execute. You will be embedded in the business and own outcomes. You’ll work closely with Commercial leadership to ensure we have the right structure, talent, and operating discipline to scale effectively, particularly in environments such as launch readiness and field force effectiveness.  This means leaning into hard conversations, making clear calls, and ensuring follow-through. Success in this role is measured by the strength of the team you help build and the results that team delivers for patients. Primary Responsibilities Partner deeply with Commercial leadership to shape org design, team structure, and talent strategy aligned to business goals. Coach and challenge leaders with direct, actionable feedback on performance, decision making, team effectiveness, and accountability. Own and drive key talent decisions (hiring, promotions, exits, succession), ensuring high standards and consistency. Operate hands-on across the employee lifecycle—from recruiting support and onboarding to performance management and development. Lead performance and feedback processes with rigor and candor, ensuring differentiation and accountability. Diagnose and address organizational friction (team dynamics, role clarity, decision-making gaps) and implement practical solutions. Remain engaged with the Field, regularly engaging with frontline teams to understand where leadership or structure needs to evolve. Build and scale operating rhythms (OKRs, talent reviews, engagement touchpoints) that improve execution and alignment. Partner cross-functionally with Recruiting, Total Rewards, and People Operations to deliver cohesive and high-quality employee experiences. Qualifications and Key Success Factors 12+ years of People (HR) Business Partnering or talent leadership experience supporting commercial or go-to-market teams in biotech/pharma, with direct exposure to pre-launch and launch stage commercial builds. Proven ability to influence senior leaders while also executing independently in a fast-paced environment. Strong business acumen: you understand how commercial organizations create (ex: field force performance, launch execution, market dynamics) value and what talent levers matter most. Experience supporting teams through scale, launch, or significant transformation with organizational design, performance management, employee relations and leadership coaching in dynamic environments. High judgment and ability to navigate sensitive situations with discretion and clarity Ability to translate business strategy into org and talent decision. The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. What will make you successful at Praxis: You are hands-on by default:  you don’t delegate work you can do faster or better yourself. You give direct, candid feedback and are comfortable engaging in difficult conversations You prioritize impact over process and avoid unnecessary complexity. You build trust quickly by being reliable, responsive, and grounded in reality. You hold a high bar for talent and are willing to make tough calls to drive team performance. You are energized by building in ambiguity and scaling from scratch. Compensation & Benefits At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together! To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles. Annualized Base Salary $200,000—$235,000 USD Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.