Praxis Precision Medicines, Inc. →
IT Support Specialist, Tier II - US based at Praxis… · Location…
ExperiencedOn-siteFull-timeNot specified$78k–$88k/yr
Job Description
Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.
The Opportunity
The Tier II IT Support Specialist is a key player in delivering seamless technology experiences across Praxis. You’ll serve as the primary escalation point for complex technical issues, partnering closely with our internal IT support, development, and leadership teams to ensure smooth operations for our 260–400 users.
From managing identity and access to administering collaboration platforms and overseeing IT assets, this role is essential to sustaining and scaling our tech infrastructure. This is a hands-on, high-impact position for someone who thrives on solving problems, documenting what works, and improving how we support our mission.
Primary Responsibilities
Level 2 End-User & Helpdesk Support
Serve as the go-to escalation point for Level 2 IT issues from our internal Helpdesk
Troubleshoot and resolve complex problems across Microsoft 365, collaboration tools, and endpoint devices
Support onboarding and offboarding workflows for employees, consultants, and contractors
Identity, Access & Authentication Management
Administer user access and authentication across Microsoft Entra ID and SaaS platforms
Manage SSO, MFA, password managers (1Password), certificates, and guest access
Handle admin consent requests and configure access for contractors and temporary roles
Email, Collaboration & SaaS Administration
Maintain shared and individual mailboxes, investigate delivery issues, and manage Mimecast settings
Administer permissions for SharePoint, DocuSign, Zoom AI, Atlassian, and other SaaS tools
Conduct periodic license reviews and audits across enterprise applications
Hardware, AV & Asset Management
Oversee laptop shipping, imaging, and inventory tracking in Jira
Manage conference room AV systems and recordings for company-wide meetings as needed to support vendors
Support mobile device setup and troubleshooting
Security & Monitoring Support
Respond to security-related alerts and support access to secure systems and VPNs
Partner with vendors and internal teams to manage OEM support and renewals
Documentation & Process Improvement
Maintain IT knowledge base in Confluence and refine workflows
Proactively identify and implement improvements to enhance support quality and user experience
Qualifications and Key Success Factors
Bachelor’s degree in IT, Computer Science, or related field—or equivalent hands-on experience
5+ years in Tier II support, service desk, or IT operations roles
Strong experience with Microsoft 365, Entra ID, N-Central and identity/access systems
Familiarity with Jira Service Management and Confluence is a plus
Comfortable supporting SaaS platforms and collaboration tools
Exceptional troubleshooting, documentation, and communication skills
A proactive, collaborative mindset with the ability to operate independently
Flexibility for occasional after-hours or on-call support
The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.
$ 78,000 – $ 88,000
These ranges reflect the base salary ranges the Company reasonably expects to pay for each level at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.
Annualized Base Salary
$78,000—$88,000 USD
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.