Software Engineer 1 at Personalis in Fremont, CA

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

We are seeking a Software Engineer I to support the development and ongoing support of our Laboratory Information Management Systems (LIMS). This role will contribute to both enhancements of existing systems and the development of modern, cloud-based platforms hosted in AWS.

You will work closely with senior engineers and cross-functional stakeholders to build reliable, scalable solutions that support laboratory operations in a regulated environment. This is an excellent opportunity for an early-career engineer to gain hands-on experience with production systems while growing skills in modern technologies.

Onsite: Monday, Tuesday, and Thursday 

Responsibilities:

• Contribute to the design, development, and maintenance of software systems supporting laboratory operations.
• Develop backend services and APIs using Python and/or Java.
• Work with relational databases and gain exposure to graph database technologies.
• Support cloud-based services and deployments in AWS.
• Participate in code reviews, testing, and technical documentation.
• Assist in troubleshooting and resolving issues across development and production environments.
• Participate in structured production support activities, including issue investigation and root cause analysis.
• Collaborate with cross-functional teams to translate business requirements into technical solutions.

Qualifications:

• B.S. degree in Computer Science, Engineering, or related technical field.
• 1–2 years of software development experience (internships and academic projects welcome).
• Proficiency in at least one programming language such as Python or Java.
• Understanding of computer science fundamentals (data structures, algorithms, object-oriented programming).
• Familiarity with relational databases and REST APIs.
• Experience using Git or similar version control systems.
• Strong problem-solving and communication skills.

Preferred:

• Experience or strong interest in healthcare, life sciences, or regulated systems.
• Exposure to AWS or other cloud platforms.
• Familiarity with Linux environments or containerization.
• Exposure to graph databases or interest in learning graph-based data modeling.
• Interest in healthcare, life sciences, or regulated systems.

What You'll Gain:

• Experience working on both existing and next-generation software platforms.
• Exposure to AWS-hosted systems and modern data technologies.
• Hands-on experience supporting production systems in a regulated environment.
• Mentorship and clear opportunities for technical growth.

The hiring range for this position is $100,000 to $130,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

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