Thought Leader Liaison (TLL) - East Coast at Karyopharm… · Remote

Role Overview & Key Functions:

The Thought Leader Liaison is a senior, field-based member of Karyopharm’s U.S. Commercial organization responsible for building and advancing strategic relationships with national, regional, and emerging thought leaders across the Eastern U.S. region. This role will play a critical part in strengthening Karyopharm’s external engagement strategy, supporting peer-to-peer education, informing brand and portfolio planning, and generating actionable marketplace insights for multiple myeloma and for emerging hematology and oncology opportunities.

Reporting to the Head of Peer-to-Peer Marketing, the Thought Leader Liaison will partner closely with Marketing, Sales, Market Access, Commercial Analytics, Medical Affairs, and other cross-functional partners to support thought leader engagement, speaker development, congress execution, regional insight generation, and compliant field-based commercial initiatives. Relevant experience in hematologic malignancies, including multiple myeloma and myelofibrosis, as well as solid tumor experience such as endometrial cancer, is highly valued.

This is a high-impact opportunity for a collaborative and externally oriented commercial leader to help shape Karyopharm’s oncology engagement model in a lean, fast-moving biotech environment. The successful candidate will operate with strategic agility, customer centricity, and strong compliance judgment while helping Karyopharm deepen relationships across the hematology and oncology community and prepare for future portfolio opportunities.

RESPONSIBILITIES:

• Lead the development, management, and execution of strategic thought leader engagement plans across the Eastern U.S. region, with an initial focus on relapsed/refractory multiple myeloma and future expansion into additional hematology and oncology indications.
• Build and maintain strong relationships with national, regional, and emerging KOLs, academic centers, community oncology leaders, and strategic accounts to support brand priorities, peer-to-peer education, and broader portfolio objectives.
• Partner cross-functionally with Marketing, Sales, Market Access, Commercial Analytics, Medical, Legal, Regulatory, and Compliance teams to inform strategy, messaging, execution planning, and field-based engagement initiatives.
• Support compliant disease-state education initiatives related to pipeline opportunities, emerging indications, and future launch readiness, ensuring alignment with approved business objectives and applicable regulatory requirements.
• Develop a structured regional insight-generation approach to capture, synthesize, and communicate external perspectives on treatment patterns, competitive dynamics, unmet educational needs, patient care pathways, and evolving stakeholder priorities; translate insights into actionable recommendations for Marketing, Sales, Market Access, Medical Affairs, and senior commercial leadership.
• Collaborate with regional sales leadership and field teams to identify educational needs, optimize HCP engagement, and drive high-quality peer-to-peer programs, speaker events, and account-based promotional initiatives.
• Represent Karyopharm at key national and regional medical congresses, advisory programs, speaker engagements, and other customer-facing events to strengthen thought leader relationships and gather actionable marketplace insights.
• Contribute to the development and execution of account-specific promotional strategies, disease-state education programs, and marketing initiatives designed to enhance awareness, engagement, and appropriate utilization of Karyopharm’s oncology portfolio.
• Provide strategic input into regional and national engagement plans by sharing field-based insights related to treatment patterns, competitive dynamics, patient care pathways, and unmet educational needs across multiple myeloma, myelofibrosis, endometrial cancer, and other relevant oncology settings.
• Support speaker bureau strategy and execution by identifying, developing, and engaging appropriate speakers; gathering feedback on program effectiveness; and partnering with Marketing and Sales to optimize peer-to-peer education in a compliant and business-relevant manner.
• Demonstrate strong business ownership, executive presence, and strategic agility while operating effectively in a fast paced, evolving commercial environment.

Candidate Profile & Requirements:

QUALIFICATIONS:

• Minimum of 7 years of experience in the pharmaceutical, biotechnology, or oncology healthcare industry.
• Experience in one or more of the following areas: oncology sales, field leadership, clinical practice, nurse practitioner experience, thought leader engagement, speaker bureau management, or peer-to-peer education.
• Demonstrated success developing and managing KOL relationships and executing strategic and tactical engagement plans in a field based or customer facing role.
• Ability to gather, synthesize, and communicate marketplace insights that inform commercial strategy, brand planning, customer engagement, and leadership decision-making.
• Strong cross-functional collaboration skills with the ability to work effectively across Marketing, Sales, Market Access, Medical, Commercial Analytics, and Compliance partners.
• Excellent communication, presentation, planning, and organizational skills, with the ability to manage multiple priorities across a large geographic territory.
• Willingness and ability to travel approximately 50% of the time, including attendance at key congresses, speaker programs, customer meetings, internal meetings, and regional field engagements.

PREFERRED QUALIFICATIONS:

• Experience and/or established relationships within hematology/oncology strongly preferred.
• Knowledge of multiple myeloma and/or myelofibrosis preferred; experience in endometrial cancer or broader solid tumor oncology is highly valued.
• Previous experience in thought leader engagement, peer-to-peer marketing, speaker bureau strategy, advisory boards, launch readiness, or disease-state education.
• Experience supporting pipeline, pre-launch, market development, or future-indication planning through compliant disease state education and insight generation.
• Demonstrated ability to influence without authority and provide strategic recommendations to senior commercial leaders.
• Strong executive presence with the ability to engage credibly with external experts, internal leadership, and cross functional stakeholders.
• Based in the Eastern U.S. / East Coast region.

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $220-260K USD.

Our Value Proposition:

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.

Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.

Learn more at Karyopharm Therapeutics.