Medical Affairs Hematology Oncology Clinical… at Karyopharm… · Remote

Role Overview & Key Functions:

The Medical Affairs Hematology Oncology Clinical Nurse Educator, Medical Affairs is responsible for the identification and engagement of a targeted group of healthcare professionals (HCPs), including physicians, nurses, nurse practitioners, physician assistants, pharmacists, and other members of multidisciplinary oncology care teams. This position provides consistent delivery of educational and compliant scientific and clinical information in support of Karyopharm’s products and pipeline.

This role will focus on education related to selinexor’s clinical profile, with an emphasis on safety, tolerability, monitoring, adverse event recognition, and supportive care considerations. The Nurse Educator will serve as a clinically credible Medical Affairs representative to care teams and will support appropriate scientific exchange, practical education, and insight generation in support of Medical Affairs launch readiness, scientific exchange and external education planning.

The Clinical Nurse Educator will operate in a non-promotional capacity and will utilize approved resources to address medical education needs, ensuring all activities are compliant with Karyopharm policies and applicable laws, regulations, and industry guidelines. RESPONSIBILITIES:

• Engage community and academic oncology care teams, including physicians, nurses, nurse practitioners, physician assistants, pharmacists, and other relevant HCPs, to understand medical education needs related to selinexor’s clinical profile, safety, tolerability, monitoring, and supportive care.
• Serve as Karyopharm’s clinical education representative to the oncology hematology community and facilitate the appropriate exchange of scientific and clinical information.
• Provide compliant, non-promotional education regarding selinexor’s clinical profile, including adverse event recognition, monitoring considerations, supportive care, dose modification concepts, and multidisciplinary care coordination.
• Educate HCPs and care teams on practical considerations related to patient management, including proactive monitoring, symptom recognition, patient counseling, communication across care team members, and appropriate use of approved educational resources.
• Utilize approved resources to address customer needs, ensuring all interactions are in compliance with Karyopharm guidelines, FDA, OIG, HIPAA, and other applicable laws and regulations.
• Appropriately triage unsolicited medical questions, including questions related to unapproved uses or emerging clinical data, to Medical Information or other appropriate Medical Affairs colleagues in accordance with company policy.
• In partnership with Medical Affairs, Medical Information, Pharmacovigilance, Regulatory, Legal, Compliance, and Clinical Development, support the development and refinement of educational resources, FAQs, field tools, training materials, and HCP-facing content.
• Provide internal education and coaching to Karyopharm colleagues on hematology oncology nursing workflows, multidisciplinary care-team dynamics, adverse-event education needs, and practical implementation considerations in academic and community oncology settings.
• Partner with MSLs to identify hematology oncology care team educational needs and provide nursing-, pharmacy-, and APP-focused clinical education, while MSLs retain primary responsibility for scientific engagement with physicians, investigators, and external experts.
• Support HCP understanding of relevant guideline updates, published data, and emerging scientific information through approved Medical Affairs processes and materials.
• Ensure timely and accurate documentation of HCP interactions, medical insights, educational needs, and follow-up activities in accordance with Karyopharm policies.
• Identify and report adverse events, product complaints, and other reportable safety information in accordance with Karyopharm requirements and timelines

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Candidate Profile & Requirements:

QUALIFICATIONS:

• Advanced clinical degree or credential preferred, including RN, NP, PA.
• 5+ years of oncology, hematology, nursing, advanced practice, pharmacy, clinical education, or Medical Affairs experience required.
• Experience in hematologic malignancies, multiple myeloma, myelofibrosis, solid tumors, oral oncology therapies, gynecologic oncology or supportive care strongly preferred.
• Product launch experience a plus.
• Clinical experience in academic and/or community hematology oncology settings beneficial.
• Strong understanding of hematology oncology practice workflows, multidisciplinary care delivery, patient education, adherence support, adverse-event management, and supportive-care principles.
• Ability to translate complex scientific and clinical information into practical, balanced education for physicians, nurses, nurse practitioners, physician assistants, pharmacists, and other oncology care team members.
• Exceptional interpersonal skills.
• Ability to excel in dynamic settings with short timelines.
• Strong written/verbal communication and presentation skills.
• Ability to establish and maintain relationships with influential HCPs and multidisciplinary care teams.
• Thorough understanding of FDA, OIG, HIPAA, and other ethical guidelines, laws, and regulations relevant to the pharmaceutical industry.
• Demonstrated ability to work cross-functionally with Medical Affairs, Medical Information, Pharmacovigilance, Clinical Development, Regulatory, Legal, Compliance, and Commercial colleagues while maintaining appropriate role boundaries.
• Valid driver’s license and the ability to travel as necessary, up to 50% including some weekends.

At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work. The anticipated base salary range for this position is $175K - $195K USD.

Our Value Proposition:

This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs.

Our lead therapy, XPOVIO® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor.

As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.

Learn more at Karyopharm Therapeutics.