Principal Scientist, Predictive Modeling… at Flatiron Health · Durham

Reimagine the infrastructure of cancer care within a community that values integrity, inspires growth, and is uniquely positioned to create a more modern, connected oncology ecosystem. We’re looking for a Principal Scientist in Predictive Modeling & Applied AI (Clinical Development) to help us accomplish our mission to improve and extend lives by learning from the experience of every person with cancer. Are you ready to be the next changemaker in cancer care? What You'll Do In this role, you will operate as a scientific leader within the Research Sciences (RS) organization, supporting our Scientific Engagement and Applied Research (SEAR) function, innovating and translating predictive modeling approaches—such as digital twins and other advanced simulation frameworks into decision grade solutions for pharmaceutical and academic partners. In this role you will propose model designs and select methodological approaches that achieve validity, interpretability, and fit-for-purpose use in clinical development. Specifically, you will: Lead the design, development, and validation of advanced predictive modeling solutions, for digital twins and other patient-level simulation approaches, in clinical development and adjacent use cases (e.g., trial design, cohort selection, endpoint prediction, treatment effect estimation, etc.) Advance a methodological strategy against existing and future use cases for applied AI in RWD/RWE by appropriate application of machine-learning, deep learning, causal inference, and multimodal modeling approaches Ensures that prediction models are scientifically rigorous, clinically grounded, and aligned to decision-oriented use cases Serve as a scientific lead in client engagements, working closely with our Life Sciences Partnership team to apply, or proactively develop, Flatiron’s modeling strategies and solutions to biopharma clinical development needs Translate complex methodological concepts into clear, decision-relevant insights for technical and non-technical stakeholders through presentations, reports and other modes of engagement Act as the organization’s external scientific engagement lead for predictive modeling and applied AI, representing the company at national and international conferences, industry forums, and through publications and scientific communications Lead authorship of abstracts, manuscripts, and external publications, establishing Flatiron as a leader in applied AI and predictive modeling Develop and disseminate training on the application of predictive models and applied AI solutions to multiple cross-functional partners in a highly matrixed environment Partner with Product, Engineering, and Data teams to shape reusable capabilities into existing or novel scalable platforms for predictive analytics Who You Are You're a kind, passionate and collaborative problem-solver who values the opportunity to think beyond the way things are. In addition, you’re a scientific leader and builder with demonstrated expertise in predictive modeling, evidenced by impactful applied work in industry or advanced academic research (e.g., thesis, publications, or equivalent projects). You are equally comfortable shaping strategy, engaging in hands-on technical work, guiding teams, and engaging directly with external partners. You have an advanced degree (MS, PhD, or equivalent experience) in a quantitative field (e.g., epidemiology, machine learning, biostatistics, data science, applied mathematics), or demonstrated equivalent expertise through applied work in predictive modeling in industry settings, including work with pharmaceutical or life sciences organizations, or academic/ healthcare systems You have demonstrated experience applying predictive modeling or AI methods to oncology clinical development, RWD/RWE, or other regulated healthcare decision-making contexts, not solely generalized enterprise or commercial AI application You are fluent across a spectrum of predictive modeling approaches spanning gradient boosting (e.g., XGBoost), deep learning (e.g., neural networks for multimodal clinical data), and advanced statistical methods for longitudinal/ time-to-event data You have strong experience in developing machine learning or predictive modeling solutions for clinical research or clinical care applications such as digital twins, clinical trial simulations You have strong familiarity with clinical development operations and processes, including clinical development planning, clinical trial design and analysis. You have strong experience in RWE methods in oncology, and are familiar with variables and endpoints commonly used in oncology RWE research, observational studies and their intersection with randomized controlled trials You are comfortable operating in a matrixed, fast-paced environment and balancing multiple high-priority initiatives You are proficient in Python OR R programming You have experience with large-scale, longitudinal healthcare datasets (e.g., EHR, claims, or multimodal data) Extra credit You have experience applying predictive modeling to other drug development areas of practice including Early development, Commercial Analytics, and HEOR You have a track record of applying predictive modeling to inform key drug development decisions across the lifecycle (e.g., target selection, trial design, go/no-go decisions, launch readiness) You have experience in clinical trial data management, analytics, and governance Where You’ll Work In this hybrid role, you’ll have a defined work location that includes work from home and 3 office days set by you and your team. For more information on our approach to hybrid work, please visit the how we work website.