Chan Zuckerberg Biohub→
Machine Learning Engineer at Chan Zuckerberg Biohub in New York, NY
Skills
Job Description
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
Biohub operates one of the largest AI compute clusters dedicated to biology, spanning three frontier research institutes with some of the world's leading biologists. We're not a startup trying to find product-market fit, and we're not a pharma company optimizing a pipeline. We're building frontier AI for fundamental science, as open science, at a scale no one else is doing. This is a unique moment for scientific acceleration. The problems are among the hardest and most impactful problems you can choose to work on, and we move at a pace that meets this moment.
Our research spans:
- Frontier molecular modeling, from protein language models (e.g., ESM) to structure prediction (e.g., ESMFold) and beyond.
- Scaled biological foundation models trained on some of the largest GPU clusters dedicated to science
- Imaging foundation models trained across the world's largest microscopy datasets
- Reasoning and agentic systems that connect frontier LLMs with biological foundation models
- Mechanistic interpretability of biological foundation models: extracting new biological knowledge directly from model weights
- Scientific data at unprecedented scale: AI systems to collect, curate, and learn from some of the richest biological datasets ever assembled
Join our Team!
As an ML Engineer, you'll join some of the strongest infrastructure engineers in AI, building the systems that connect everything together. The infrastructure problems you solve directly determine what science becomes possible.
What You'll Do
- Build and maintain pre-training infrastructure across thousands of GPUs.
- Design and optimize GPU-native data loading pipelines for scientific data workloads at petabyte scale.
- Build I/O and pipeline systems for biological data unlike anything in standard AI: microscopy volumes, transcriptomics, spatial genomics.
- Define the abstractions that researchers will build on for years.
- Own the ML lifecycle: artifact tracking, fine-tuning pipelines, monitoring, and production reliability.
- Build the DevOps and tooling that make every engineer and researcher more productive.
- Deploy Biohub's technology, powering the tools scientists use worldwide.
What You'll Bring
We're looking for engineers who've built infrastructure for large-scale ML systems and are energized by problems that don't have existing solutions yet.
- Hands-on Pytorch: custom training loops, distributed training, or low-level performance work
- GPU-native data I/O and large-scale tensor formats (Zarr, HDF5, TensorStore)
- Distributed computing frameworks (Spark, Dask, Ray)
- Docker and Kubernetes
- A track record of building systems that other engineers and researchers depend on
- Experience in building AI agent frameworks is a plus
Compensation
The future anticipated Redwood City, CA, and New York City, NY base pay range for a role in this field is $150,000 to $350,000+ annually. Compensation ranges will vary based on job-related skills, level of experience, and knowledge. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
Please note that applying to this opportunity does not guarantee that we will be in touch with you regarding our opportunities. Our recruiting team will contact you if your experience aligns with the skills we seek for future open positions. We will keep your interest on file, contact you as opportunities arise, and send you information about the exciting work we are doing at Biohub. You can opt out at any time!
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