Associate Scientist, In vivo Pharmacology,… at Amgen · US -…

Summary: Amgen is a biotechnology company focused on serving patients with serious illnesses. The Associate Scientist role involves working in a dynamic in vivo pharmacology team to execute preclinical disease models and support pipeline programs through hands-on in vivo and in vitro work. Responsibilities: - Perform hands-on in vivo work primarily mice, possibly rats in the vivarium daily - Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down - Work side-by-side with Scientists/Senior Scientists to execute and help design experiments - Run concurrent studies, stay organized and detail-oriented to meet study timelines - Participate in weekend/evening dosing rotations as needed - Support in vitro assays as required - Communicate results to immediate team and follow established protocols and safety procedures - Work in a flexible team-oriented environment. Weekend and evening work may be required Required Qualifications: - Master's degree and 1 year of Immunology or related experience - OR - Bachelor's degree and 3 years of Immunology or related experience Preferred Qualifications: - M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity - Strong understanding of Immunology and Inflammation biology and principles - Willingness and curiosity to learn and explore new areas of research - Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in Asthma, COPD, HS, PBC a plus - Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection) - Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential - Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word - Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential - Demonstrated track record of independent critical thinking and scientific achievement - Demonstrated experience in pharmacology and in vivo models of inflammation/Immunology Required Skills: Immunology, vivo pharmacology, Preclinical disease models Important Skills: Flow cytometry, GraphPad Prism Nice-to-Have Skills: Data analysis Benefits: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts, A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan, Stock-based long-term incentives, Award-winning time-off plans, Flexible work models where possible.