Associate Scientist, In vivo Pharmacology,… at Amgen · US -…

Summary: Amgen is a biotechnology company focused on serving patients with serious illnesses. The Associate Scientist in In vivo Pharmacology will execute preclinical disease models and in vitro assays, providing technical support and collaborating with senior scientists to design experiments. Responsibilities: - Perform hands-on in vivo work primarily mice, possibly rats in the vivarium daily - Provide technical support for studies, dosing, sample/tissue collection, health checks, study setup and take down - Work side-by-side with Scientists/Senior Scientists to execute and help design experiments - Run concurrent studies, stay organized and detail-oriented to meet study timelines - Participate in weekend/evening dosing rotations as needed - Support in vitro assays as required - Communicate results to immediate team and follow established protocols and safety procedures - Work in a flexible team-oriented environment. Weekend and evening work may be required Required Qualifications: - Master's degree and 1 year of Immunology or related experience - Bachelor's degree and 3 years of Immunology or related experience Preferred Qualifications: - M.S. degree in Immunology or related disciplines, or B.S. degree with commensurate scientific / drug discovery experience and track record of scientific excellence and productivity - Strong understanding of Immunology and Inflammation biology and principles - Willingness and curiosity to learn and explore new areas of research - Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis (DSS, CD45RBhi T cell transfer, IL-10 KO), lupus (NZB/W, MRL-lpr, Imiquimod), and arthritis (CIA, CAIA), GvHD models preferred. Experience in Asthma, COPD, HS, PBC a plus - Hands-on experience with in vivo techniques including dosing route of administration (i.v., i.p., p.o., i.n., i.t., r.o., i.d., s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung, lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection) - Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements) preferred. Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential - Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word - Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential - Demonstrated track record of independent critical thinking and scientific achievement - Demonstrated experience in pharmacology and in vivo models of inflammation/Immunology Required Skills: vivo pharmacology, Immunology expertise, Preclinical disease models Important Skills: Flow cytometry, Biochemical assay techniques, Data analysis Benefits: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts, A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan, Stock-based long-term incentives, Award-winning time-off plans, Flexible work models where possible.