Sr. Software Engineer - Full Stack

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Personalis is based in Fremont, California.

Summary:

You are expected to work with a highly talented staff of diverse expertise to clarify requirements, develop next generation software that will assist our comprehensive end-to-end human genome sequencing and analysis products.

This position will enrich your experience in all phases of the software development lifecycle allowing you to simplify, invent, build and engineer best in class products.

Onsite: Monday, Tuesday, and Thursday

Responsibilities:

• Architect, design, and modernize application software including dashboards, workflow management systems, reporting platforms, and web portals.
• Design and develop highly robust, scalable, and user-centric software systems supporting sample processing, order management, and report delivery.
• Automate operational workflows to reduce manual processes and enhance system stability.
• Design, develop, and maintain system integration interfaces for internal platforms and external partners, supporting healthcare data exchange standards such as HL7 and FHIR, and lead technical discussions to define interface contracts and implementation strategies.
• Develop backend services using Java and Python, and build user-facing applications using ReactJS and modern web technologies.
• Implement and manage containerized deployments using Docker and Kubernetes, and build and maintain CI/CD pipelines using Jenkins to support automated testing and deployment across on-premise and AWS environments.
• Identify system bottlenecks, conduct code reviews, and implement architectural improvements to support growing operational demands.
• Provide production support, perform root cause analysis, and drive continuous system enhancements.

Education and Experience:

• Bachelor’s degree or higher in Computer Science, Computer Engineering, or a related technical field.
• 5+ years of professional experience in software development, including development of user-facing and enterprise-grade applications.
• Strong proficiency in Java (Spring Boot) and ReactJS.
• Experience with modern web standards and technologies, including ES6, HTML5, and CSS3.
• Solid understanding user experience principles and web application design best practices.
• Experience with full-stack development, including web protocols and web server optimization techniques.
• Familiarity with microservices architecture and containerization technologies such as Docker and Kubernetes.
• Experience working in fast-paced environments and delivering high-impact solutions within defined timelines.
• Strong communication and interpersonal skills, with the ability to collaborate effectively across cross-functional teams.
• Prior experience in biotech, healthcare, or genomics environments is a plus.

The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

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