Research Associate/Senior Research Associate, In Vivo Pharmacology

Summary: Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines. They are seeking a highly-motivated In Vivo Pharmacology Senior Research Associate to execute in vivo studies that support internal research projects. Responsibilities: - Conduct in vivo mouse studies, including dosing via IV, IP, SQ, and other routes as needed - Perform necropsy, tissue dissection, perfusion, and blood/tissue collection (in-life and terminal) - Perform blood collections via submandibular cheek bleeds and cardiac punctures - Prepare and process tissues for downstream analysis - Accurately label samples, track collection, and maintain comprehensive records - Follow protocols rigorously and contribute to protocol refinement when needed - Ability to follow SOPs and work independently in a high-throughput setting - Maintain accurate and organized data entry and analysis - Collaborate with cross-functional teams in a dynamic research environment - Strong attention to detail with excellent data organization and recordkeeping - Assist in maintaining inventories Required Qualifications: - Bachelors or Masters and 1-2+ years of experience (biotech/pharma industry preferred) in executing in vivo pharmacology experiments in mice - Demonstrated expertise executing hands-on in vivo studies - Collaborative, curious, and flexible with strong communication skills, both written and oral - Self-motivated, highly organized, able to work independently with minimal supervision, and able to multitask - Strong attention to detail - A genuine passion for science and developing medicines Preferred Qualifications: - Familiarity with histology, microscopy, or tissue sectioning - Experience in bioanalytical assays for protein therapeutics (PCR, nucleic acid extraction, ELISA, Western Blot, etc) - Skilled with common data analysis and productivity software such as Microsoft Office, GraphPad Prism, and ImageJ - Experience writing detailed research project plans and methodological SOPs that guide yours and other team members' laboratory activities - Experience in mouse health monitoring is highly preferred Required Skills: vivo pharmacology, Mouse dosing techniques, Necropsy, Tissue dissection, Tissue perfusion, Blood collection, Sample processing, Histology, Microscopy, Protein therapeutic bioanalytical assays, PCR, Nucleic acid extraction, ELISA, Western Blot, Research data analysis software, Microsoft Office, GraphPad Prism, ImageJ, Laboratory SOP development, Mouse health monitoring Benefits: Annual performance-based target bonus, Stock options, Comprehensive medical, dental, and vision coverage, 401(k) plan, Flexible paid time off and holidays, Perks including on-site gym, onsite lunch, and commuter support